![]() ![]() ![]() Paul from Salford, United KingdomThe song is actually a tribute to Billy Connolly.luckily my Boston Pandora station played it and now I can't stop listening to it.Stealers Wheel is genius! ![]()
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![]() ![]() A brief summary of significant new information from the previous year that might affect the safety, effectiveness, or labeling of the drug product. The report is required to contain in the order listed: Each annual report is required to be accompanied by a completed transmittal Form FDA 2252 (Transmittal of Periodic Reports for Drugs for Human Use), and must include all the information required under this section that the applicant received or otherwise obtained during the annual reporting interval that ends on the U.S. approval of the application, two copies of the report to the FDA division responsible for reviewing the application. The applicant shall submit each year within 60 days of the anniversary date of U.S. (ii) Information concerning any bacteriological contamination, or any significant chemical, physical, or other change or deterioration in the distributed drug product, or any failure of one or more distributed batches of the drug product to meet the specification established for it in the application. (i) Information concerning any incident that causes the drug product or its labeling to be mistaken for, or applied to, another article. The report and its mailing cover should be plainly marked: "NDA - Field Alert Report." The information may be provided by telephone or other rapid communication means, with prompt written followup. The applicant shall submit information of the following kinds about distributed drug products and articles to the FDA district office that is responsible for the facility involved within 3 working days of receipt by the applicant. The applicant shall submit to the Food and Drug Administration at the specified times two copies of the following reports: Each applicant shall make the reports for each of its approved applications and abbreviated applications required under this section and section 505(k) of the act. PART 314 - APPLICATIONS FOR FDA APPROVAL TO MARKET A NEW DRUG The information on this page is current as of Mar 28, 2023.įor the most up-to-date version of CFR Title 21, go to the Electronic Code of Federal Regulations (eCFR). ![]() ![]() ![]() ,acdc,abcd123,crash1,colony,delboy,davinci,notebook,nitrox,borabora,bonzai. ![]() * Detailed Help/Documentation for explaining all the functions and features and much, much more!įor certain devices, it's also possible to use built in Android pop-up views to get an easy way to switch between the game and the Notebook Wind Assist tool on a single device. ,hooters,startrek,captain,maddog,jasmine,butter,booger,golf,rocket,theman. * Catalog of tournaments and courses coupled with annotated tutorial videos * Over 1500 searchable hole tutorials to show you the best ways to play a hole for virtually any given situation * Needle Trainer to improve your shot timing for all clubs, tours & tournament levels ![]() * Min, Mid, Max slider range which not only reports the 3 key values, but all values in between * Multi-bag support for easy club switching * Full Screen Wind Calculator which shows how many rings you need to adjust for all clubs more suitable for using on a 2nd device * Wind Calculator Overlay capabilities to give you in-game adjustments If you are looking for an aide that will help you adjust faster and more precisely, then this is the tool for you! This app has been built and designed by top players of the Golf Clash community whose primary focus is providing you with the best, most reliable information we've gathered for over a year. If you love playing Golf Clash and want to lower your scores, this tool will help make adjustments simple and easy! He made the comments just hours before Andy Farrell’s men take on. We have been assured by Playdemic that any store based apps that continue to include overlay capabilities will cease to work with Golf Clash in the near future. US President Joe Biden has backed the Irish Rugby team to secure the Grand Slam in today’s crunch match against England. The multi-instance feature can be very helpful in Golf Clash as it enables you play multiple battles/competitions simultaneously taking the joy of playing the game to a whole new level.Fan made training app to help you master the game of Golf Clash. With multi-instance, you can play different accounts, instances, or games simultaneously, making things more fun and exciting. Through BlueStacks 5 macros feature, you can record, replay and send a video of your gameplay, sharing your brilliant moves with friends and having fun watching previous gameplays. BlueStacks 5 makes it easier for you to switch between multiple accounts or profiles as it saves your other profiles allowing you to change through different profiles in one click. BlueStacks app player is the best platform to play this Android game on your PC or Mac for the best gaming experience.ĭownload Golf Clash using BlueStacks on a PC with at least 4GB RAM and gain access to features such as real-time translation, macros, multi-instance, and change device profile available on BlueStacks 5 to give you a mesmerizing experience.īlueStacks 5 offers Real-Time Translation, which enables you to communicate with different players worldwide in your language and understand theirs as a result of BlueStacks 5 translating in real-time for you. Click and Play instantly!Įxperience a relaxing time playing golf in Golf Clash, a sports game developed by ELECTRONIC ARTS. You can also Play Golf Clash in your browser on your PC or mobile without downloading. Download Golf Clash today and show them how good you are at golf. ![]() Thousands of players are available to play the game, looking for who will challenge them for their spot or ways to climb up the ladder and be at the top. Get promotions in leagues occurring weekly to win bonuses and tournaments every two weeks to be the top player.Ĭhat with opponents in the chat section during the game, share replays of matches or specific shots, and work with teammates to get rewards for clans. There is a revolutionary shot system that you can use for the gold that is difficult to master but might be what you need to win, so surpass your limits, train and get better to win every battle. More golf courses are added every month.Įnjoy quick-fire duels in real-time against real-life opponents. Play golf on multiple beautiful courses against different opponents worldwide, and challenge your Facebook friends in tournaments and 1vs1 battles. BlueStacks app player is the best platform to play this Android game on your PC or Mac for an immersive gaming experience.ĭownload Golf Clash on PC while the sun is still out to play a multiplayer golf game everyone is talking about life. Golf Clash is a sports game developed by ELECTRONIC ARTS. ![]() ![]() ![]() In a 2012 interview, Lana Wachowski said: It has been created to keep the minds of humans docile while their bodies are stored in massive power plants, their body heat and bioelectricity consumed as power by the sentient machines that have enslaved them. After his rescue and convalescence aboard Morpheus's ship, Morpheus shows him the true nature of the Matrix: a detailed computer simulation of Earth at the end of the 20th century (the actual year, though not known for sure, is suggested within the original movie to be approximately 200 years later, though it is revealed through sequels The Matrix Reloaded, The Matrix Revolutions and The Animatrix that at least 700 years have passed). Neo takes the red pill and awakens in the real world, where he is forcibly ejected from the liquid-filled chamber in which he has obliviously been lying. The red pill, on the other hand, serves as a "location device" to locate the subject's body in the real world and to prepare them to be "unplugged" from the Matrix. you stay in Wonderland, and I show you how deep the rabbit hole goes." It is implied that the blue pill is a sedative that would cause Neo to think that all his most recent experiences were a hallucination, so that he can go back to living in the Matrix's simulated reality. the story ends, you wake up in your bed and believe whatever you want to believe. In the film The Matrix, the main character Neo (played by Keanu Reeves) is offered the choice between a red pill and a blue pill by rebel leader Morpheus (played by Laurence Fishburne). The terms originate from the 1999 film The Matrix. The red pill and blue pill represent a choice between the willingness to learn a potentially unsettling or life-changing truth by taking the red pill or remaining in the contented experience of ordinary reality with the blue pill. Red and blue capsule pills, like the ones shown in The Matrix (1999) ![]() ![]() It also supports shell integration (command line interface and scripting). PowerISO is a fairly easy-to-use application that uses a simple drag-and-drop user interface and the (now standard) ability to copy/paste from the clipboard. Due to these advanced features, PowerISO is the only software package that can read the. daa file format allows advanced features such as file compression, password protection, encryption and the ability to split files in to multiple volumes. ![]() Unlike the majority of CD/DVD image formats, the. daa file extension stands for 'Direct Access Archive' and was created by PowerISO Computing for their CD/DVD image file-processing tool "PowerISO". Full Movie is to import all titles, Main Movie is to import the longest title by default, and Custom Mode is to freely choose titles for importing.The. Note: There are three modes available: Full Movie, Main Movie and Custom Mode. Once DVD content is selected, you will be provided three options for you to import DVD file(s). Click "Add Blu-ray/DVD" to import the ISO file. Media to enter the home page, and click "DVD Ripper" to get into the converting interface. Now keep reading to learn how to convert ISO media file to video with Leawo DVD Ripper. You can also customize the file you have created, you can merge multiple DVD titles into a single file, trim video length, add video watermark, crop video size, adjust video effect, and add 3D video effect. What is more, compared with other DVD ripping software on the market, Leawo DVD Ripper is 6 times faster in DVD ripping and converting. However, is it possible to convert ISO media file to video? Of course, you need to complete the task with a well-known third party, the Leawo DVD Ripper.Īs we all know, Leawo DVD Ripper allows you to convert ISO media file to video, to extract audio content from source DVD and save in various audio formats like AAC, FLAC, WAV, MP3, etc., and it allows you to directly set device model as output profile. With Leawo DVD Creator, we can easily convert video to ISO. Bonus: How to convert ISO media file to video with Leawo DVD Ripper ![]() Click the Burn button at the bottom of the sidebar to start burning video to ISO with Leawo DVD Creator. Click "DVD Creator" to enter the main interface. ![]() Download and launch the Leawo DVD Creator. ![]() Check out to find how to convert video to ISO with Leawo DVD Creator. And it can preserve the quality of the original video while burning the video to DVD and ensures that the DVD playback would look just as good as the original video. Furthermore, for DIY enthusiast, this is the perfect DVD Creator to convert video to DVD as it gives users the power to change their disc menu templates and the items on the disc menu. It is well known that Leawo DVD Creator is equipped with the ability to convert video to DVD, which supports more than 180 formats, for instance, videos in formats like AVI, MKV, MP4, WMV, Xvid, MOV, and FLV can be burnt to DVD-9 and DVD-5 discs. To convert video to ISO, Leawo DVD Creator is a wise choice. Therefore, we will introduce another accredited software. Part 2: How to convert Video to ISO with Leawo DVD Creator?īut, what if the file you need to convert isn't one of these types of files and these free ISO converter can not satisfy your need? There are many formats that are not video, audio, image, or document based. ![]() ![]() ![]() Use traps and environmental hazards to your advantage - fire, spike pits and rotating crushers hurt your enemies as well as you!.Creatures work together to chase you down, flee from threats and fight each other for dominance. ![]() Battle a variety of intelligent enemies, each one determined to make your escape as difficult as possible.From the cold slimy walls of the dungeon to the hot fiery pits of hell, TinyKeep is a visual treat. Explore a variety of beautiful but deadly environments.Watch your step as it can be your last! Extremely challenging Permadeath gameplay.Procedurally generated random dungeons – no playthrough is ever the same!.There are many ways to survive in TinyKeep. You can also take advantage of monster rivalries and lead them against each other, while you wait behind a corner as the resulting chaos ensues. ![]() Enemies will work together in groups to hunt you down, and some will flee from threats. Lure monsters into traps, knock over fire torches to set the dungeon alight and set prisoners free to help you on your way. With nothing but a flickering lantern and a strange letter left behind by their in-mate, they must venture into the darkness and escape TinyKeep! Their savior is nowhere to be seen, but the cell door is broken and ajar, tempting them with the sweet scent of freedom. In TinyKeep players will embrace the role of a hopeless prisoner held deep in a forgotten dungeon who one day wakes up to find themselves mysteriously released. RegionsÅland Islands, Albania, Algeria, Andorra, Angola, Anguilla, Antarctica, Antigua and Barbuda, Argentina, Armenia, Aruba, Australia, Austria, Azerbaijan, Bahrain, Bangladesh, Barbados, Belarus, Belgium, Belize, Benin, Bermuda, Bhutan, Bolivia, plurinational state of, Bosnia and Herzegovina, Bouvet Island, Brazil, British Indian Ocean Territory, Brunei Darussalam, Bulgaria, Burkina Faso, Burma, Burundi, Cambodia, Cameroon, Canada, Cape Verde, Cayman Islands, Central African Republic, Chad, Chile, China, Christmas Island, Cocos (Keeling) Islands, Colombia, Comoros, Congo, Congo, Democratic Republic of the, Cook Islands, Costa Rica, Cote d'Ivoire, Croatia, Cuba, Curaçao, Cyprus, Czech Republic, Denmark, Djibouti, Dominica, Dominican Republic, Ecuador, Egypt, El Salvador, Equatorial Guinea, Eritrea, Estonia, Falkland Islands (Malvinas), Faroe Islands, Fiji, Finland, France, French Guiana, French Polynesia, French Southern Territories, Gabon, Gambia, Georgia, Germany, Gibraltar, Greece, Greenland, Grenada, Guadeloupe, Guatemala, Guernsey, Guinea, Guinea-Bissau, Guyana, Haiti, Heard Island and McDonald Islands, Holy See (Vatican City State), Honduras, Hong Kong, Hungary, Iceland, India, Ireland, Isle of Man, Israel, Italy, Jamaica, Japan, Jersey, Jordan, Kazakhstan, Kenya, Kiribati, Korea, Republic of, Kuwait, Kyrgyzstan, Lao People's Democratic Republic, Latvia, Lebanon, Lesotho, Liberia, Liechtenstein, Lithuania, Luxembourg, Macao, Madagascar, Malawi, Malaysia, Maldives, Mali, Malta, Marshall Islands, Martinique, Mauritania, Mauritius, Mayotte, Mexico, Micronesia, Federated States of, Moldova, Monaco, Mongolia, Montenegro, Montserrat, Morocco, Mozambique, Namibia, Nauru, Nepal, Netherlands, New Caledonia, New Zealand, Nicaragua, Niger, Niue, Norfolk Island, Northern Mariana Islands, Norway, Oman, Palau, Palestinian Territory, Occupied, Papua New Guinea, Paraguay, Peru, Philippines, Pitcairn, Poland, Portugal, Qatar, Republic of North Macedonia, Reunion, Romania, Russian Federation, Rwanda, Saint Barthélemy, Saint Helena, Ascension And Tristan Da Cunha, Saint Kitts and Nevis, Saint Lucia, Saint Martin (French Part), Saint Pierre and Miquelon, Saint Vincent and the Grenadines, San Marino, Sao Tome and Principe, Senegal, Serbia, Seychelles, Sierra Leone, Singapore, Sint Maarten, Slovakia, Slovenia, Solomon Islands, Somalia, South Africa, South Georgia and the South Sandwich Islands, South Sudan, Spain, Sudan, Suriname, Svalbard and Jan Mayen, Swaziland, Sweden, Switzerland, Taiwan, Province of China, Tajikistan, Tanzania, United Republic Of, Thailand, Timor-Leste, Togo, Tokelau, Tonga, Turkey, Turkmenistan, Turks and Caicos Islands, Tuvalu, Uganda, Ukraine, United Arab Emirates, United Kingdom, United States, United States Minor Outlying Islands, Uruguay, Uzbekistan, Vanuatu, Venezuela, Vietnam, Virgin Islands, British, Wallis and Futuna, Western Sahara, Zambia, Zimbabwe ![]() ![]() ![]() The modifications can be to the PDF object structure like removing To be more specific, it is easily possible to read an existing PDF with HexaPDF and modify parts of Prawn is a library for generating content. The main difference between HexaPDF and Prawn is that HexaPDF is a full PDF library whereas HexaPDF itself is distributed via Rubygems and therefore easily installable via gem install On cmdparse, a command line parsing library. The hexapdf application has an additional dependency Written and provided by the HexaPDF authors. ).Īpart from Ruby itself the HexaPDF library has only one external dependency geom2d which is Platform supported by Ruby (Linux, macOS, Windows. HexaPDF works on all Ruby implementations that are CRuby compatible, e.g. Higher as prior versions are not supported! Official installation documentation for details. Since HexaPDF is written in Ruby, a working Ruby installation is needed - see the With example graphics and PDF files and tightly integrated into the rest of the website. It is recommend to use the HTML API documentation provided by the HexaPDF website as it is enhanced write ( " hello-world.pdf " )įor detailed information have a look at the HexaPDF website where you will the API font ( ' Helvetica ', size: 100 ) canvas. PDF file: require ' hexapdf ' doc = HexaPDF :: Document. Here is a "Hello World" example that shows how to create a simple ![]() When HexaPDF is used as a library, it can be used to do all the task that the command lineĪpplication does and much more. The applicationĬan be used to perform common tasks like merging PDF files, decrypting or encrypting PDF files and The HexaPDF distribution provides the library as well as the hexapdf application.
![]() ![]() Each island features 3 modes of play (Normal, Challenge, and Expert), plus Sandbox mode lets you play with no limits and even more control over how the world behaves. Optional bonus objectives and other hidden bonuses will reward more creative builders and add further replayability. While some vehicles will perform better than others in accomplishing your objectives, it's always a bit more fun to get creative and go a little off script. Each new part unlocks countless new possibilities, and you'll also unlock numerous pre-built vehicles that highlight the unlocked parts and provide inspiration for further experimentation. Using an intuitive vehicle construction system that also lets you customize your vehicles' appearance and controls, you'll always have fun creating your next awesome invention.įrom simple splitters and joints to fully-simulated treads and ropes, a large variety of parts are available to start the game, while more advanced parts (like giant chainsaws and rocket thrusters) unlock by playing the game. Each element of the world complements the destruction system and interacts with each other and together they create a physical, visceral world to play with.īuild a vehicle your way, with an ever-expanding array of parts and pieces. The game also features an advanced GPU-driven particle system and GPU-driven grass and surface rocks. You can demolish every structure in the game piece by piece thanks to a fully interactive physics system, and every object in the world interacts with the destruction in some way. Our app is compatible with hundreds of the best PC games and available now.Instruments of Destruction features an advanced physics-based destruction system. ![]() It's the perfect way to track Instruments of Destruction FPS drops and stutters.ĭownload our free FPS Monitor via Overwolf to count your frame rates as you play, and test how tweaks to your settings can boost FPS and increase Instruments of Destruction performance. How many FPS will I get on Instruments of Destruction?Īn FPS Monitor is the first step in understanding how the parts in your gaming PC are actually performing in real-world conditions. Instruments of Destruction FPS - what frame rate can you expect? We'll help you find the best deal for the right gear to run the game. Filter for Instruments of Destruction graphics card comparison and CPU compare. ![]() Looking for an upgrade? Try our easy to use Instruments of Destruction set up guides to find the best, cheapest cards. Instruments of Destruction will run on PC system with Windows 7 or later and upwards. You will need at least 600 MB of free disk space to install Instruments of Destruction. Whereas, an Intel Pentium 4 4.00GHz is recommended in order to run it. An Intel Pentium 4 1.50GHz CPU is required at a minimum to run Instruments of Destruction. If possible, make sure your have 16 GB of RAM in order to run Instruments of Destruction to its full potential. The minimum memory requirement for Instruments of Destruction is 8 GB of RAM installed in your computer. ![]() Furthermore, an NVIDIA GeForce GTX 970 is recommended in order to run Instruments of Destruction with the highest settings. The cheapest graphics card you can play it on is an NVIDIA GeForce GTX 780. ![]() ![]() Some dash cams have special requirements for SD cards. Fix 2: Check the Technical Information of Your Dash Cam If the dash cam not reading SD card persists, you can try the next fix. After that, you can turn on your dash cam and check if the camera can successfully read the card. ![]() This time, you need to make sure that the gold contacts of the card are facing toward the dash cam and the card should be pushed until it clicks into place. If your SD card is not working on dash cam, the first thing you should do is turn off the dash cam, remove the SD card, and then reinsert it into the slot. There are files (not video recordings) on the SD card.īased on the above reasons, we propose the following solutions.The SD card is damaged or has bad sectors.The SD card is not compatible with the dash cam.The SD card is not properly inserted into the dash cam.Top Reasons for Dash Cam Not Recognizing/Detecting/Reading SD CardĪfter collecting users’ reports, we find that dash cam will not detect the SD card when one of the following things happens: Now, we will show you the information related to dash cam not recognizing SD card, including how to fix the problem and how to rescue your files from the SD card. What to do to recover the recordings in the SD card if it is unreadable?.How to avoid the data loss issue when solving the problem?.What is the reason for dash cam not recognizing SD card?.For example, your dash cam doesn’t recognize, detect, or read the inserted SD card. However, you may encounter different kinds of issues when using a dash cam. When your dash cam successfully recognizes the SD card, it will begin to store the recordings. You need to insert an SD card into the dash cam to save the recordings. Fix 4: Remove the Existing Files on the SD Cardĭash Cam Not Recognizing/Detecting/Reading SD CardĪ dash cam is a driving recorder that continuously records the view through a vehicle’s front windscreen and sometimes rear or other windows.Fix 2: Check the Technical Information of Your Dash Cam.Top Reasons for Dash Cam Not Recognizing/Detecting/Reading SD Card.Dash Cam Not Recognizing/Detecting/Reading SD Card.However, you’d better first recover your recordings using MiniTool Power Data Recovery to keep them safe before fixing the problem. ![]() But if your dash cam can’t detect the SD card, do you know how to fix the problem? In this post, MiniTool Software will introduce some easy and effective methods. ![]() This sometimes works because even though files are deleted from the hard drive, the hard drive isn't necessarily overwritten, so some deleted files may still be retrievable.You need to use your dash cam with an SD card to save the recordings. What this does is it tries to scan your Mac's hard drive's empty space for files that were deleted. Third party data recovery software, on the other hand, is what you use when you do not have an actual backup to rely on. (As a side note, the latest version of OS X includes a Versions feature that makes locally stored backups of older versions of files, so if you change a document, you can still see what it used to be.) Then if you lose a file, you can grab a copy from this backup. In this way, you always have a copy of everything, including versions going back in the past (depending on how large the external hard drive is). When your computer is connected to an external hard drive and Time Machine is turned on, every hour it backs up the files on your computer (or any files changed since the previous backup). Time Machine is a bit different from third party data recovery software. ![]() ![]() Additionally, depending on your commitment to holding onto your data (so, for business, you might have a 6 year or 12-month retention policy) there are ways to make economies in between the stages. The cost of a 2-stage backup (i.e having 2 backups of your data) operation can be measured by the amount of data you/your company produces on a daily basis. How Expensive is a 2-Stage Backup and Do I need it? Below is a video that breaks down a number of different Backup and Redundancy methods inside a single NAS system: If the NAS server or RAID enabled DAS box does, then there is a very high chance that your data cannot be recovered via these methods (not impossible, just touch and certainly not foolproof). Think of RAID/Snapshots/Versioning as ‘safety nets’, The only work from INSIDE the infrastructure NOT outside of it. These are NOT backup methods and are actually designed primarily as a means of recovering your data in the event of an HDD/SSD dying, an accidentally deleted file or rolling a file back to a previous revision. Way, WAY too many NAS (network-attached storage) or DAS (direct-attached storage) owners think their data actually have a backup layer in place when they refer to their RAID configuration, their versioning or their snapshots. Backup and Redundancy – DO NOT GET THEM MIXED UP! Today I want to focus on the 2nd and 3rd stages of your backup routine and help you decide the best ways to spend your budget on the most effective safety net and recovery system for your needs. Stages 2 and 3 should be encrypted in case they are stolen/entered, as well as feature login credentials and an admin system in the event of them being occupied/accessed illegally. This can range from another NAS, to a cloud provider and even a USB drive) Off-site/different location Backup (where the copy of the on-site backup lives that is separate network and/or physical location.On-site Backup solution (where multiple devices are backup’ed up to internally, also more commonly referred to as the bare-metal backup).Primary Data (Where data is initially created/collected, the PCs, the Macs, the Phones, etc).Take a moment and think how much it would cost your business right now if you lost your data – hundreds? Thousands? Close the business? The ideal backup solution should always be based on the cost of loss, not gain! Although a little trite, it is still a reliable rule of thumb to have a 3-2-1 backup solution operation that looks like this: Your personal media (family, events, memories), your client’s data or perhaps your surveillance data. ![]() No, you have to think about how much will this data cost you to LOSE. If you think like that, you will never move past stage one. So ultimate you have to stop thinking about this only in terms of how much this storage is going to cost. Sadly this is true, because not only do you put yourself at risk of complete critical loss in the event of fire or flooding, but also in the case of theft you end up having all your eggs in one basket and making the thieves lives much easier. Worse still if you have all the machines in your home or office backing up to a device in that same location, almost all data safety and storage experts will scream to high heaven that this is still not enough. You are spending all this money on what can be described as a remarkably large insurance policy. You will spend hundreds, if not thousands of pounds on storage, then you find out that you need to have it in ANOTHER location too (as otherwise, it isn’t truly a backup) and then worse still it isn’t even being spent on making more space, but actually to duplicate your old data and not be used. Centralized backup is a very unappealing idea. It is all too easy to rely on your data living on multiple machines in your office or home. ![]() If you found this article thanks to a rather perceptive google search, then clearly you think data is very important too. That should not come as a staggering fact. I know it is not going to be shocking news when I say that Data is really, really important. 14.2 Related What is the Best Way to Backup Your Data Every Day? ![]() |